HPV symptoms - Human Papilloma Virus: emerging trends in detection and management.
Wright JD, Herzog TJ. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine.
Cervical cancer continues to be a major epidemiologic problem in developed and underdeveloped nations alike. Current screening practices rely on cervical cytology for the early detection of cervical neoplasm that relate to HPV symptoms. It has now been demonstrated that over 99% of cervical carcinomas are positive for Human Papilloma Virus (HPV) DNA. This article reviews the currently available methods of HPV detection as well as emerging strategies for the implementation of HPV testing into clinical practice to determine what HPV symptoms you might be displaying.
Credit: Entrez-PubMed
Curr Womens Health Rep 2002 Aug;2(4):259-65
HPV symptoms - Viral load of Human Papilloma Virus and risk of CIN3 or Cervical Cancer
Lorincz AT, Castle PE, Sherman ME, Scott DR, Glass AG, Wacholder S, Rush BB, Gravitt PE, Schussler JE, Schiffman M. Digene Corporation.
Carcinogenic Human Papilloma Viruses (HPV) are thought to be necessary for development of cervical cancer. We assessed whether higher viral loads of such viruses predicted future risk of CIN3 or cancer (CIN3+) in a cohort of 20810 women followed up for 10 years with cytological screening. We measured the viral load for 13 types of carcinogenic HPV (relative light units normalized to 1 pg/mL HPV 16 positive controls [RLU/PC]) using Hybrid Capture 2 testing of cervicovaginal lavages obtained at enrolment. Results were stratified into four groups (RLU/PC 1 to <10, 10 to <100, 100 to <1000, > or = 1000). Although presence of HPV strongly increased risk of CIN3+, high viral load did not further predict risk of CIN3+.
Credit: Entrez-PubMed
Lancet 2002 Jul 20;360(9328):228-9
HPV symptoms - Importance of Human Human Papilloma Virus for the development of skin cancer.
Meyer T, Arndt R, Christophers E, Nindl I, Stockfleth E. Institute of Immunology, Pathology and Molecular Biology, Hamburg, Germany.
The frequent detection of HPV DNA in non-melanoma skin cancers was shown in several studies; however, the role of HPV symptoms in the development of these cancers remains speculative. We analyzed different skin tumors, normal skin, and hair follicles for HPV DNA using a PCR system designed to detect all HPV types known so far. HPV DNA was found in 93% of common warts, 69% of squamous cell carcinomas (SCC), 52% of basal cell carcinomas (BCC), 41% of actinic keratoses, 31% of extragenital Bowen's disease, 22% of keratoacanthomas, 16% of normal skin tissues and 47% of hair follicles. No individual HPV symptom or type predominated in any of the skin tumors. The number of HPV genomes in individual neoplasms (SCC and BCC) seems to be less than I per cancer cell. These results indicate that a direct role of HPV in skin cancerogenesis remains questionable. Possibly, mechanisms different from the activity of HPV oncoproteins in genital cancers are involved in skin neoplastic transformation.
Credit: Entrez-PubMed
Cancer Detect Prev 2001;25(6):533-47
